Stem Cell Therapy- THE LEADING LIGHT,THE VISIONARY

Dr Alok SHARMA and his role in Stem CellTherapy- THE LEADING LIGHT,THE VISIONARY

Dr Alok Sharma is not only a neurosurgeon, he is a neuroscientist too.Way back in he year 1996, when all neurosurgeons were doing the traditional stabilization of the spine in a spinal cord injury patient, his thoughts went deeper than the superficial stabilization. He saw the pain and helplessness in the eyes of a quadriplegic left to waste away.He realised that even if the vertebral column is stabilized,the spinal cord is damaged and is not functional. That’s when he started researching deeper and came across stem cells and stem cell therapy as a possible tool for the regeneration of the severed spine!

He travelled overseas to study the science of stem cells, to understand the potential and research the intricacies of the stem cells and regenerative science.

He worked on foetal stem cells and embryonic stem cells in the USA labs.However, in view of the political upheavals and controversy surrounding the embryonic stem cells,he started reviewing other types of stem cells.He found that adult stem cells appear to be the most promising of all types of stem cells.

Once back in India, as the professor of neurosurgery in the one of the largest Municipal corporation hospital LTGMCand H ,he converted unused laboratory space into a stem cell laboratory to start work on adult stem cells. He worked on various types of regenerative cells such as Olfactory ensheathing cells and finally found bone marrow derived stem cells to be most accessible,pluripotent and amiable for use in transplantation medicine.His earliest experiment were on laboratory rats. Once safety was established he treated the first subacute spinal cord injury patient with the his own bone marrow derived stem cells. These cells were injected into the spinal cord around the area of injury,during the spine stabilization process. This was one of his earliest successes, way back in 2007. This individual slowly improved, was is able to walk with minimal support, has got married and has a 2 years old daughter too!!!!

Recent Advances In Autism Management

This Autism Awareness Week, NeuroGen BSI brings you its two stalwarts, Director & Consultant Neurosurgeon, Dr Alok Sharma, & Deputy Director & Head of Medical Services, Dr Nandini Gokulchandran! 

Catch them LIVE & interact with them in their Free Webinar on “Recent Advances In Autism Management”! 

Simply register below!

https://www.facebook.com/NeuroGenBSI

Save Your Spot!

4th April 2020, Saturday

Time:

3PM - 4PM (IST)

10:30 AM - 11:30 AM ( Nigeria, Cameroon, Congo)

11:30 AM - 12:30 PM ( South Africa, CEST, Zambia, Burundi, Lesotho,) 

12:30 PM - 1:30 PM (Kenya, Tanzania, Uganda, Ethiopia)

1:30 PM - 2:30 PM (Dubai/UAE, Mauritius, Seychelles)

5:30 PM - 6:30 PM (SGT)

7:30 PM - 8:30 PM (AEST)

You’re Invited

Parents, Caregivers, Rehabilitation Experts, Medical Practitioners or other Autism professionals!

You Will Learn About

• Benefits of Cellular Therapy in Autism
• Factual Published Data Supporting Stem Cell Transplantation for Autism.

More About Dr. Alok Sharma

Dr Sharma, an award winning Neurosurgeon, has contributed academically & clinically to the field of neurosurgery, globally. While specialising in cellular therapy for neurological disorders, he has treated almost 10,000 patients. He’s also a Professor & Head of Department of Neurosurgery at Sion Hospital & Medical College, and a Consultant Neurosurgeon at Fortis Hospital, Mumbai. 

More about Dr. Nandini Gokulchandran

A postgraduate in Microbiology, Dr Nandini did her Fellowship in Developmental Neurology & Stem Cell Research from Tata Institute of Fundamental Research, Mumbai. She’s published over 14 books and 90 scientific publications in national and international journals.

Stem Cell Therapy to Solve Neurological Problems such as Autism

Stem-Cell Therapy to Solve Neurological Problems such as Autism?

Part — 1| | Maruthuvam Arivom | Autism — causes, symptoms, diagnosis, treatment, pathology | Autism in Tamil | Autism Tamil | autism treatment in tamil | Stem-cell therapy in Tamil | stem cell therapy for autism | Hindu Tamil Thisai | 

Autism : A serious developmental disorder that impairs the ability to communicate and interact. Autism spectrum disorder impacts the nervous system and affects the overall cognitive, emotional, social and physical health of the affected individual. 

 

Stem-cell therapy : Stem cell therapy is the use of stem cells to treat or prevent a disease or condition. Bone marrow transplant is the most widely used stem-cell therapy, but some therapies derived from umbilical cord blood are also in use.

Watch a detailed explanation in Tamil 

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on what is autism and it’s cause and how stem cell therapy can change the way we treat autism spectrum disorders with Dr. Nandini Gokulchandran.

Join the Free Webinar on “Head Injury - Recovery Through Regenerative Medicine And Holistic Rehabilitation” by Neurosurgeon, Dr Richa Bansod & Physiotherapist, Dr Shreedip Patil (PT), this Friday, 20th March. 

Interact one-on-one with the speakers after the Webinar!

Simply register below!

https://bit.ly/2TOg4rD

You’re Invited

Patients & Caregivers, Physicians, Neurologists, Neurosurgeons & Rehabilitation Experts!

You Will Learn About

·         Recent Advances in Managing Head injury 

·         Evidence & Benefits of Regenerative Medicine in Repairing Brain Damage

·         Importance of a Holistic Rehabilitation approach in Acute & Chronic Head Injury Patients

·         Effects of Arousal Therapy and NDT in Acute Head Injury Patients.

More About Dr. Richa Bansod and Dr. Shreedip Patil

Dr Richa Bansod is the Head of the Department of Surgery and Dr Shreedip Patil (PT) is a Neuro physiotherapist at NeuroGen Brain and Spine Institute. Dr Richa received her medical degree, then trained in Neurosurgery and holds a Master’s degree in Hospital Administration (MHA). Dr Shreedip specializes in Neurological conditions such as head injury, stroke, spinal cord injury, Ataxia Autism and Neuromuscular conditions.

See you on Friday, 20th March!

Improvements In A Case Of Sensory Ataxia Through Cell Transplantation

Sensory ataxia is a type of ataxia that is caused by the loss of sensory input to control the movement of  the body.  It is both a sign and a symptom. There have been no curative modalities for treating sensory ataxia. Cellular therapy has gained significant attention as a therapeutic option for various neurological disorders. 

We present a case of an 18-year-old female diagnosed with sensory ataxia who was intrathecally administered with autologous bone marrow mononuclear cells (BMMNCs) along with neurorehabilitation. 

Twelve months after cellular therapy, signs such as ataxia, postural tremors, intention tremors and dysmetria improved. Functional Independence Measure score improved from 106 to 107. Berg Balance Scale improved from 18 to 34. Brief Ataxia Rating Scale improved from 7 to 5. Modified International Cooperative Ataxia Rating Scale improved 26 to 24. Comparison of the Positron Emission Tomography Computed-Tomography (PET CT) image before and 12 months after cellular therapy showed improved metabolism in bilateral sensory motor cortex, thalamus and cerebellum. These PET findings correlated with symptomatic improvements. 

The clinical improvements along with PET CT findings suggest that cellular therapy is a beneficial therapeutic modality for sensory ataxia. No major adverse effects were seen. Further clinical studies should be conducted to understand the efficacy of cellular therapy in sensory ataxia.  Read more...

Dr Alok Sharma Stem cells | Stem cell therapy | NeuroGen

A stem cell is an undifferentiated cell of a living organism. It has the potential to proliferate or regenerate, repair the organ or tissue after an injury as well as give birth to more differentiated cells. A term that can be associated with the potential of stem cells is "plasticity", which implies that a stem cell can be isolated from one tissue and convert itself into cells of different tissues. While there are several experienced doctors from all over the world, who have done extensive research in the field of regenerative medicine, Dr Alok Sharma has carved his niche ́ in the field of stem cells for neuroregenerative purposes. In India, Dr Alok Sharma, stem cells & incurable neurological disorders go hand-in-hand. 

Which stem cells does Dr Alok Sharma use?

 Dr Alok Sharma’s stem cell preference is adult autologous bone marrow derived, as it is one of the safest and most effective types of stem cells for neurological disorders. DrAlok Sharma’s stem cell therapy center at NeuroGen Brain & Spine Institute, uses the following protocol for treatment of incurable neurological disorders. The stem cell transplantation is divided into 3 simple and effective steps:

Bone Marrow Aspiration:

The bone marrow is a soft sponge like material that forms blood cells and is a rich source of adult stem cells for stem cell therapy. Dr Alok Sharma uses a thin bone marrow aspiration needle for the bone marrow extraction from the patient’s own hip bone, which is easily accessible. This extraction is done under local anaesthesia. After this, the patient is sent back to their room to rest for the next step.

Stem Cell Separation:

The bone marrow aspirate is then transferred to the stem cell laboratory for processing. Dr Alok Sharma’s stem cell laboratory is fully equipped GLP (Good Lab Practice) & GMP (Good Medical Practice) certified. The stem cell separation takes advantage of the differences in density between the varieties of cells found in the aspirate and the density gradient medium. The separation process takes around 3 to 5 hours.

Intrathecal Stem Cell Injection:

Once the BM MNCs are separated and purified in about 3-4 hours, the patient is taken back to the operation theatre, where Dr Alok Sharma administers stem cells intrathecally, i.e. into the fluid around the brain and spine, using a spinal needle. In certain cases, these stem cells are injected into the muscles (eg. Muscular Dystrophy patients - as assessed and recommended by the rehabilitation team) using a very thin needle. 

Dr Alok Sharma is considered as one of the best neurosurgeons in the world and has been recognised several times in both, Indian & International platforms. He has touched the lives of over 8500 individuals from over 65 countries, who suffer from various incurable neurological disorders. Dr Alok Sharma’s stem cell therapy can be done at his neurological hospital in India, NeuroGen Brain & Spine Institute. The stem cell transplantation is followed by extensive neurorehabilitation done by some of the best therapists in India. You can also contact Dr Alok Sharma for stem cell therapy here.

Nobel Prizes in Stem Cell Research

There are times in human history when quantum leaps occur in our thinking and approach towards the various issues we face as a race. The world of medicine and healthcare has witnessed one such landmark in the past decade. That is, the revolutionary field of cell therapy, which was awarded the prestigious Nobel Prize in Physiology or Medicine in the year 2012. This Nobel Prize was awarded jointly to British scientist Sir John B. Gurdon and Japanese stem cell researcher Shinya Yamanaka for the discovery that mature cells can be reprogrammed to become pluripotent.

Nobel Prizes in Stem Cell Research

Dr E Thomas, 1990

Demonstration of stem cells in bone marrow

Sir Martin Evans, 2007

Isolation of embryonic stem cell in mice

John B Gurdon, 2012

Mature, specialized cells can be reprogrammed to become
immature cells capable of developing into all tissues of the body

Shinya Yamanaka, 2012

Mature, specialized cells can be reprogrammed to become
immature cells capable of developing into all tissues of the body

About Cell Therapy
Regenerative medicine is a game ­changing and rapidly evolving field of modern medicine. It is focused at repair, restoration and replacement of damaged tissues by a safe and effective administration of living cells either in solitude or in combination with specially engineered materials. Regenerative medicine itself isn’t new; the first bone marrow and organ transplants were carried out decades ago. Technological advances in developmental and cell biology, immunology, and other fields have ushered in a new era of therapeutic strategies to refine existing regenerative therapies and develop novel ones. These therapies are beneficial for a multitude of disorders that today, are beyond repair. This includes neurological disorders like autism, cerebral palsy, muscular dystrophy, spinal cord injury, brain stroke, traumatic brain injury, etc. Current research in the field of regenerative medicine utilize stem cells to create functional tissues to regenerate damaged or injured organs and tissues.