Sensory
ataxia is a type of ataxia that is caused by the loss of sensory input to
control the movement of the body. It is both a sign and a symptom. There have
been no curative modalities for treating sensory ataxia. Cellular therapy has
gained significant attention as a therapeutic option for various neurological
disorders.
We present a case of an 18-year-old female diagnosed with sensory
ataxia who was intrathecally administered with autologous bone marrow
mononuclear cells (BMMNCs) along with neurorehabilitation.
Twelve months after
cellular therapy, signs such as ataxia, postural tremors, intention tremors and
dysmetria improved. Functional Independence Measure score improved from 106 to
107. Berg Balance Scale improved from 18 to 34. Brief Ataxia Rating Scale
improved from 7 to 5. Modified International Cooperative Ataxia Rating Scale
improved 26 to 24. Comparison of the Positron Emission Tomography
Computed-Tomography (PET CT) image before and 12 months after cellular therapy
showed improved metabolism in bilateral sensory motor cortex, thalamus and
cerebellum. These PET findings correlated with symptomatic improvements.
The
clinical improvements along with PET CT findings suggest that cellular therapy
is a beneficial therapeutic modality for sensory ataxia. No major adverse
effects were seen. Further clinical studies should be conducted to understand
the efficacy of cellular therapy in sensory ataxia. Read more...
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